الفهرس 
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Abstract
Obesity is a state of excessive body weight associated with adverse
health risks such as diabetes, hypertension, hyperlipidemia and coronary
artery disease. Obesity has become a global problem affecting all
societies and age groups. There is an increased prevalence of obesity
among adults, adolescents and children in developed as well as
developing countries. Localized adiposity is not directly associated with
obesity and can be present in non-obese individuals with fat accumulation
in specific regions of the body.
Liposuction has long been one of the most popular treatment
modalities in obesity. Aesthetic body contouring with liposuction requires
a complete knowledge of the anatomic, biochemical, and physiological
basis of liposuction. Additionally, liposuction is associated with many
risks and down time.
Carbon dioxide (CO2) therapy, or carboxytherapy, is the
administration of medical CO2 for therapeutic proposals. It was
demonstrated that injection of CO2 used as an alternative measure to be
associated with liposuction procedures. It showed efficacy in treating
localized adiposity and skin irregularities.
The aim of the present study was to evaluate efficacy and safety of
injection of CO2 in treatment of localized fat deposits.
The present study was carried out on thirty-four female patients with
localized fat deposits in chin, arm, abdomen and thigh. They were
selected from Dermatology Outpatient Clinic, Faculty of Medicine,
Menoufia University Hospitals from July 2017 to January 2018.
All patients received treatment sessions by CO2 once weekly for 8
weeks, or till-improvement which is first. Evaluation of the studied patients was done by tape measurements, digital photographic evaluation
and ultrasonic examination, as well as patient‘s own satisfaction.
The result of the present study showed that:
1. Abdomen measurements by tape and US showed a statistically
significant reduction in abdominal circumference (P < 0.0001), and
in fat thickness (P < 0.0001).
2. Arm measurements by tape and US showed a significant reduction
in the circumference (P =0.0003), and in fat thickness (P =0.0004).
3. Thigh measurements by tape and US showed a significant
reduction in the circumference (P < 0.0001), and fat thickness (P <
0.0001).
4. Chin measurements by US showed a statistically significant
reduction in fat thickness (P = 0.012).
5. The percentage of circumference reduction in the 3 body regions
(abdomen, upper arm, and thigh) showed that there was a
statistically significant difference (p=0.001). That was significantly
higher in arm (7.9±2.3) followed by thigh (7.2±2.1) and ended by
the abdominal area (4.1±1.9).
6. By US, the reduction in fat thickness was observed in chin
(60.6±10.1) followed by the thigh (43.03±11.0) then abdomen
(34.7±15.2) and finally the arm (25.8±6.7) (p<0.001).
7. One week after the last session, half of our patients 17 (50%)
revealed excellent degree of satisfaction, with a statistically
significant difference between the patients according to the region
of treatment (p =0.027), where the highest satisfaction rate was
among patients who had lipolysis in the chin region (100%).
8. Ecchymosis and pain were the only observed adverse effects,
regarding pain, it ranged from mild to moderate, and occurred at
time of sessions and subsided 2-3 hours after injection without any
analgesics.