الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
PART1: Synthesis of imidazol-thiadiazole derivatives (1-10):
Reaction of chalcon (E)-3-(2-hydroxyphenyl)-1-(naphthalene-2-yl)prop-2-en-1-0ne with H2O2 in the presence of sodium hydroxide in NaOH and acetone with stirring up on 1\2h afforded the corresponding epoxide (II). When epoxide allowed to react with 2 amino-s-aryl thiadiazole afforded imidazol-thiodiazole (1-10) derivatives.PART2: Synthesis of azacoumarin derivatives (1-10):
The one-pot reaction of chalcone, 2-substituted ethyl acetate, and ammonium acetate in which they were subjected to react in a multi-component reaction (MCR) by grindstone chemistry, together without using tetrahydrofuran (THF) for 25–30 min. Afterward, the reaction mixture was left overnight at room temperature to yield crude yellow solid products (11-13). Four pot reaction of chalcone, diethylmalonate and urea in the presence of ammonium acetate under ultrasonic reaction conditions afforded the pyridopyrimidine 14. Authentic reaction of stirring the azacoumarin 13 with urea in ethanol at (50-60oC) afforded the desired product 14. Moreover, sonication of the chalcone, diethylmalonate, urea and aniline afforded the product 15. Furthermore, reaction of chalcone with active methylene heterocyclic precursor such as 5-phenyl pyrazol-3-one in the presence of ammonium acetate afforded the product 16. On the other hand, sonication of the chalcone, and ethyl cyanoacetate in the presence of hydrazine hydrate or phenyl hydrazine, it afforded the diazepine derivatives 17 or 18 respectively.By repeating the former reaction when it replaced the ethyl cyanoacetate by ethyl benzoyl acetate. It will be afforded the product 19,20.