الفهرس 
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Abstract
Summary
Atrial septal defect (ASD) is a common form of congenital heart disease, accounting for nearly 5%-10% of all congenital cardiac defects in children. Closure of these defects is generally indicated in children to prevent the development of congestive heart failure and pulmonary hypertension. Interventional ASD closure is considered the first choice whenever applicable, it is safe, superior to surgical ASD closure with regard to patient morbidity, shows fewer complications.
Our study is retrospective randomized study after approval by internal ethical committee and will be conducted on patients with ASD large device closure following up at Pediatric cardiology outpatient clinic, Cairo University Hospital. It will involve 80 pediatric patients divided into two groups. group one consists of 40 patients with ASD closure by large device after more than 1 year closure. group two consists of 40 control children. To report the outcomes and mid-term follow-up of transcatheter closure of ASD by a large device by tissue Doppler and 2-D, 4-D Speckle Tracking and MRI heart and to detect RV function and early signs of complications.
Regarding the patients age ranged from 2 years to 16 years with male: female ratio 40%:60%. The controls age from 3 years to 15 years with male 45% and females 55%.
In our study there is no statistically significant difference between patients and controls regarding volumes and strain of both left ventricle and right ventricle by 2-D and 4-D echocardiography.
And there is no statistical difference between cases and controls regarding cardiac MRI parameters of both Right and left ventricle dimensions and function.
In comparison between both right and left ventricular volumes and function parameters by the three modalities (2D, 4D echocardiography and CMR) there were no significant statistical differences between them.
Finally, our findings suggest that both right and left ventricular volumes and functions regaining to normal values after 1 year follow up post ASD device closure with no complications could be detected.