الفهرس 
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Abstract
Sepsis in neonates hospitalized in the NICU is a global problem and is a significant contributor to morbidity and death. The clinical manifestations are non-specific and indistinct from those caused by various neonatal noninfectious disorders.
Early recognition and diagnosis of neonatal sepsis are difficult but is extremely important because rapid introduction of antimicrobial therapy improves outcomes. Isolation of bacteria from a central body fluid (usually blood) is the gold standard and most-specific method to diagnose neonatal sepsis.
The high-affinity Fc receptor, Neutrophil CD64 is quantitatively upregulated during infection and sepsis, under the effect of inflammatory cytokines; this rise happens in a graded manner dependent on the intensity of the cytokine stimulus. CD64 expression is stable for more than 24 hours. Technological progress has made it possible to quantitate neutrophil CD64 quickly, with accuracy, and with minimal blood volumes.
In this study we selected CD64 to test its value in the early diagnosis of neonatal sepsis cases by using ELISA. The current study also aimed to evaluate its relationship with the different demographic, clinical and laboratory data.
This study was carried out on 74 patients; 26 culture proven sepsis patients, 25 suspected sepsis patients and 23 control patients. All patients were subjected to complete history taking, thorough clinical examination and laboratory investigations including: CBC, blood culture, CRP and CD64 assay.
Results
• The most prominent signs of neonatal sepsis were feeding intolerance ,mottled skin, respiratory distress, mechanical ventilation , oedema , poor suckling, poor moro and irritability.
• PROM more than 18 hours was the most important risk factor of neonatal sepsis.
• The most common isolated organisms was Klebsiella, followed by streptococcus pneumoniae then Staphylococcus .
• A positive correlation was shown between CRP and CD64 .
• The mean CD64 expression in neonates with sepsis was significantly higher than those in the control group.
• No statistically significant associations were elicited between CD64 expression and gestational age and sex in the studied cases.
• Positive correlation between CD64 expression and CRP has been found .
For CD64 expression.