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Abstract The main target of the present investigation was to study the effect of white, black, and sprouted garlic (5%) as treatment and protection on the diabetes mellitus albino rats. Thirty two male albino divided into three main groups. The first group (4 rats) fed on basal diet as a (control groupve), while in the second main group (16 rats) diabetes mellitus was induced in normal healthy albino rats by intraperitoneal injection of alloxano 150 mg/kg body weight at the beginning of the experimental period. The second main group divided into four groups (4 rats each). Groups (1) fed on basal diet (control positive group +ve). Groups (3-5) (treatment groups) fed on basal diet containing 5% white, black and sprouted garlic respectively. For the third main group (12 rats) diabetes mellitus was induced in normal healthy albino rats by intraperitoneal injection of alloxano 150 mg/kg body weight on the 26th day of the experimental period. The third main group divided into three groups (4 rats each). Groups (6-8) (protection groups) fed on basal diet containing 5% white, black and sprouted garlic respectively. At the end of the experimental period (28 days) rats were fasted over night before sacrificing, blood was collected then centrifuged to separate the serum. Liver, kidneys, lungs, heart and spleen removed from each rat, cleaned and weighted to estimate of organs weight. The obtained results revealed that, treatment by alloxan led to significant increase in serum glucose, cholesterol, triglycerides, LDL, VLDL, uric acid, urea, creatinine, AST, ALT and ALP, and decreased HDL. Treating rats which were injected by alloxan with the levels from white, black and sprouted garlic (5%) showed decreased levels of serum glucose, kidney function, liver function, LDL & VLDL, and increased serum HDL. Also improved the other parameters including internal organs weights. Key words: Diabetes mellitus, Glucose, Kidney function, Liver function, Lipid profile. ABSTRAC |