الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Thiosemicarbazones have showed antiviral, antitumor, antibacterial, antimalarial and antifungal properties. Besides the significant pharmacological properties of the thiosemicarbazones, they also characterized by interesting and versatile mode of chelation in their complexes. Water is the perfect solvent for synthetic processes from an economic and ecological industrial point of view. With keeping these applications in mind and in extension of our research program concentrated on separation of medicinally powerful novel water-soluble thiosemicarbazone and the corresponding complexes in addition to their biological estimation. The current study is planned to improve the water solubility and the bioactivity of the thiosemicarbazone and its metal complexes, we introduced a SO3 group to the phenyl ring of salicylaldehyde-thiosemicarbazone with the goal of preparation of a water-soluble ligand. The current interest in thiosemicarbazone is due to the presence of various donor atoms (N, S-donors), which exhibit diverse bonding modes leading to different structural motifs.The main aim of the present thesis is focused on the preparation and characterization employing elemental analyses, thermal (TG and DrTG), spectral (IR, UV-Visible, 1H NMR, Mass and ESR), magnetic measurements, photochemical activity and biological activities of new complexes of sodium (E)-4-hydroxy-3-((2-(pyridin-2-ylcarbamothioyl)hydrazineylidene) methyl) benzenesulfonate (NaH3PyTSC) with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Cd(II), Zn(II), Hg(II) and U(VI)O2 metal ions.