الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
Summary
Psoriasis is an inflammatory disease with chiefly skin and joint involvement. It has a bimodal age of onset and affects both sexes similarly.
At present, the most accepted theory is that psoriasis is an immunemediated inflammatory cutaneous disease which manifests in a genetically prone person exposed to some environmental agents or triggeres.
Endoplasmic reticulum (ER) is a sophisticated luminal network where protein synthesis, maturation, folding, and transport occur. Homeostasis in the ER can be monitored and maintained through unfolded protein response(UPR).
A role of ER stress in epidermal cell proliferation and migration is under extensive research.
A number of stimuli (psychological ,biological, or pathological) can disturb protein folding in the ER, that lead to accumulation of misfolded or unfolded proteins in the ER lumen – a condition called “ER stress”.
This current work was done to explain the role of ER stress in the pathogenesis of Psoriasis vulgaris and to identify its correlation with disease severity.
The study included 25 psoriatic patients, and 25 healthy volunteers serving as control group.
The results of the present study showed noteworthy difference between cases & controls as regards ER stress.
Finally, the present study fulfilled that ER stress may have an essential task in the pathogenesis of psoriasis.