الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 59 |  |  |
| | | from | 59 | | |
Abstract
Summary
The use of intravitreal anti VEGF agents has been revolutionary in the field of vitreoretinal practice and these agents are now used in multiple conditions in all regions of the world. With the use of these agents came the realization that anterior segment changes can occur even with the use of minute quantities of the drug of Lucentis in the range of 0.1-0.05 ml.
The aim of this study was devised to evaluate the effect of (0.5mg 0.05ml) Lucentis intravitreal injection (as a treatment for DME, CRVO or Active CNV) on the central corneal thickness and the anterior segment of the eye using Anterior Segment OCT.
This study was carried out on 50 eyes of 50 patients, 30 of them were diagnosed DME, 13 were diagnosed CRVO with macular edema, 7 were diagnosed Active CNV. all the cases received monthly intravitreal injection of Lucentis along 3 months and evaluated by AS-OCT one month after every injection and 4 months after the third injection.
Patients were excluded if they had history of ocular trauma, anterior segment pathology, previous ocular surgery, any ocular pathology like uveitis, any systemic disease other than diabetes mellites.
Before injection patients were subjected to detailed ophthalmic evaluation including best corrected visual acuity, anterior segment examination, intraocular pressure measurement, fundus examination with slit lamp biomicroscopy, AS-OCT to measure central corneal thickness.
Patients were evaluated by AS-OCT for central corneal thickness measurement and appearance of any anterior segment neovascularization for 6 consecutive months after injection.
There was no statistically significant change in CCT along the 6 monthly follow up evaluation by AS-OCT. As for Anterior segment neovascularization, it was detected in 1 patients after 3 months of injection and another 2 patients after 4 months of injection and another 2 patients after 5 months of injection with total of 5 patients at the end of the study. There was no statistically significant difference among all time points as regards the incidence of ASN.