الفهرس 
Epidermal langerhans cellsOnly 14 pages are availabe for public view
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Abstract
Summary
Bleomycin is one of the first prescribed chemotherapeutic agents that has been used for cancer treatment for many years. Despite the development of new drugs in oncology, bleomycin remains an important component of chemotherapy regimens for germinative tumors and Hodgkin’s lymphoma. On the other hand, bleomycin has common side effects on lung and skin.
Scleroderma is an autoimmune disease manifested by painful digital ulcers, joint contracture, beak-shaped nose, reduced aperture of the mouth (microstomy), radial furrowing around the mouth and skin thickening. Moreover, the patient’s face becomes expressionless, mask-like and appears ‘mummified’. Scleroderma is caused by genetic and environmental factors. Bleomycin-induced scleroderma in animals exhibits definite dermal sclerosis mimicking human scleroderma.
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have become a recent focus of interest in tissue regeneration due to their easy isolation and culture. Previous experiments proved that BM-MSCs have an important role in amelioration of tissue fibrosis caused by various diseases such as stroke and myocardial infarction. Therefore, BM-MSCs may be considered as an attractive tool in the therapy of some skin lesions such as burn, psoriasis, and alopecia.
Aim of the work:
The aim of this work was to study the effect of bleomycin on the skin of adult male albino rats and the possible curative role of MSCs using histological and immunohistochemical techniques.
Materials and methods:
This study was performed on 45 adult male albino rats. They were divided into two main groups:
1-Control group: It included 15 rats for histological a.