الفهرس 
Multi drug resistant bacterial and fungal pathogensOnly 14 pages are availabe for public view
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Abstract
The search for bioactive metabolites including novel antibiotic compounds from microbial sources for potential use in agricultural, pharmaceutical, and
industrial applications has become more important due to the development of
drug/multi-drug resistance in most of the pathogenic microbes. Researchers
across the globe are aggressively searching for new, potent, sustainable, and broad- spectrum antimicrobial compounds from various sources including
microbes. Actinomycetes are diverse group of Gram positive bacteria that
usually grow by filament formation. Actinobacteria are widely distributed is
both terrestrial and aquatic ecosystems, mainly in soil, where they play an essential role in recycling refractory biomaterials by decomposing complex mixtures of polymers in dead plants animals and fungi. Since hot spring environment differs greatly from terrestrial habitats, the biological
characteristics of actinomycetes and their distribution are expected to be
different from those of soil actinomycetes, Furthermore, the hot spring environment is proving to be a major source of new natural products,
especially antimicrobial compounds, most notably those expressed by
actinomycetes. Antibiotics and other bioactive compounds from actinomycetes are renowned for their antibacterial, antifungal, neuritogenic, anticancer, antialgal, antimalarial, and anti-inflammatory activities. In this study, twenty four actinomycete isolates were isolated on starch-nitrate agar medium from different hot springs in Egypt (Helwan,Sewa oasis, and Pharaoh’s bath hot spring). The isolates were screened for antimicrobial activity against eight multi-drug resistant bacterial species E.coli, P. mirabilis, P. aeruginosa, S. typhimurium, K. pneumonia, Staph.aureus, B. cereus, L. monocytogenes and six fungal species T. mucoides, C.albicans, C. glabrata, C. krusie, C. dublinesis and C. tropicalis by using wellagar diffusion method. Out of 24 isolates, the promising results were recorded by isolates act.17,act13, and act.4 against Staph. aureus, P. aeruginosa and C. tropicalis,therefore, they were selected for further work.