الفهرس 
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Abstract
People with DS form the largest group of persons with intellectual disability. Enhanced knowledge regarding comorbidity could improve the quality of life of people with DS who often have difficulty communicating their signs and symptoms.
Good medical care has been shown to not only improve their life expectancy but also to help maintain patients in active vocational and group-living programs. Part of this comprehensive care involves an understanding and appreciation of the dermatological manifestations of DS and how they could impact both the medical and psychological health of the patient. DS shows increased frequency of some common dermatoses. Some dermatologic manifestations in DS can be in relation with their immunological alterations. Skin alterations of DS have been observed by few studies. Their management is equal to the rest of patients, but they can occasionally be more resistant to conventional treatment, for example AA.
Atopic dermatitis is one of the most frequent skin diseases associated with DS. However, perhaps this high association observed in first studies could be overestimated. Newer studies, which have used criteria of Hanifin and Rajka to diagnose AD, does not show so higher incidence of AD in DS. SD can be more extensive than in other patients. Some immunologic skin diseases, as vitiligo and AA, have been reported with high incidence in DS. Other miscellaneous cutaneous lesions were probably coincidentally seen in every study. It‟s easy to fall into thinking that everyone with Down syndrome looks a certain way and has certain abilities, and that‟s the end of the story. But it‟s hardly reality. While Down syndrome affects people both physically and mentally, it‟s very different for each person and there‟s no telling early on what its impacts will be. For some people, the effects are mild. They may hold jobs, have romantic relationships, and live mostly on their own. Others may have a range of health issues and need help taking care of themselves. No matter what symptoms a person with Down syndrome has, early treatment is the key. With the right care to develop physical and mental skills and treat medical issues , children with Down syndrome have a much better chance to reach their full abilities and live meaningful lives.