الفهرس 
Sleep disordered breathingOnly 14 pages are availabe for public view
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Abstract
VII- Summary and Conclusions
Sleep disordered breathing (SDB) refers to repetitive process
of respiratory impairment which may be partial or complete and
occur during sleep.
Obstructive sleep apnea (OSA) is the most common form of
sleep disordered breathing and represents a major public health
problem that affects approximately 6–13% of middle aged group and
19–37% of elderly. It is caused by repetitive collapse of a narrow
upper airway during sleep with periodic cessation of breathing (>10
second). These events usually result in oxyhaemoglobin desaturation
and fragmented sleep, leading to excessive daytime sleepiness,
cognitive dysfunction and impaired work performance.
Oxidative stress, endothelial dysfunction, and hypoxemiarelated
activation of the sympathetic nervous and renin-angiotensinaldosterone
systems that occur in OSA induces kidney injury and
leads to development of chronic kidney disease.
Cystatin C is a low-molecular-weight protein from the family
of cysteine protease inhibitors that could be considered as a novel
marker of kidney function and is more sensitive than creatinine for
detecting glomerular filtration because it is produced by nucleated
cells and is freely filtered at the glomerulus but not secreted by the
tubule.
This study aimed to evaluate serum levels of cystatin C in
otherwise healthy obstructive sleep apnea patients in predicting the
future risk of latent renal impairment and cardiovascular diseases in
these group of patients.