الفهرس 
IVFOnly 14 pages are availabe for public view
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Abstract
With the advent of IVF, it has been established that the luteal phase of all stimulated IVF cycles is abnormal. The aetiology of luteal phase defect in stimulated IVF cycles has been debated for more than two decades. The role of p supplementation in the luteal phase of down regulated cycles is well established. Progesterone supplementation is a routine treatment throughout the world with different doses and types of administration. The benefit of additional luteal supplementation with E2 is controversial. Objective: The aim of this study is to compare the pregnancy outcome if we use progesterone (prontogest) only versus the use of progesterone (prontogest) and estradiol valerate (cyclopregnova) as a luteal phase support in IVF Patient and method; This study included 60 women divided into two groups: 1. group 1 consists of 30 patients who received vaginal administration of progesterone supplementation in the form of 400mg prontogest twice a day starting on the day of oocyte retrieval and if the chemical pregnancy test was positive it is continued until the tenth week, this group was divided into two groups : A. Ovarian stimulation was done GnRH agonist protocol.B. Ovarian stimulation was done by GnRH antagonist protocol.2. The second group consists of 30 patient in which 2 mg estradiol valerate in the form of cyclopregnova is initiated twice daily with prontogest suppositories on the day of oocyte retrieval and if the chemical pregnancy test was positive it is continued until the tenth week, this group was divided into two groups: A. Ovarian stimulation was done by GnRH agonist protocol. B. Ovarian stimulation was done by GnRH antagonist protocol. Results: In this study we have compared the luteal phase support with progesterone only with the luteal support with estrogen and progesterone in agonist and antagonist groups. The findings suggest that the pregnancy rate is higher with the estrogen and progesterone supplementation than the progesterone only supplementation in both groups who underwent GnRH agonist or antagonist suppression protocol but it has not reached a statistically significant value.