الفهرس 
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Abstract
This study was performed on 100 ILD patients that referred to Cardiothoracic Minia University Hospital in the period from March 2017 to March 2018.
The study included 652 patients with pulmonary diseases other than ILDs that admitted to the hospital at same the period as a control group.
All the patients had been subjected to the following:
Full detailed history taking included (age, sex, smoking status, other special habits, history of dust exposure, duration of illness and symptoms).
General examination.
Local chest examination, 6MWT.
Investigation included:
Radiological: chest x-ray and HRCT of the chest.
Pulmonary function tests.
Echocardiography.
Laboratory: ABG, CBC and collagen profile.
According to ATS/ERS consensus multidisciplinary approach for ILD diagnosis [Travis et al., 2013], the distribution of ILD cases was hypersensitivity pneumonitis (51%) followed by IIP (26%), unclassifiable ILD (13%) and lastly CTD-ILD (10%). On analysis the demographic data of the studied patients it was found that most of the patients of ILDs aged 45-60 years old, the disease occur more in females than males, more in rural areas than urban, and more in housewives with bird’s breeding history, and most of the patients are nonsmokers.
As regard clinical characteristics of ILD patients, we found that dyspnea and dry cough were the most frequent symptoms of ILD with a nearby frequency among ILDs subtypes.
Chest pain and clubbing were significantly found in unclassifiable ILD group than the other ILD types.
Regarding pulmonary function tests, it was found that restrictive defect was the most frequent one encountered and the mean FVC and FEV1% predicted were significantly higher in patients with hypersensitivity pneumonitis than other types. There was no significant difference for 6 minute walk test between ILDs types.
Pulmonary hypertension, GERD, arterial hypertension and DM were the most frequent comorbidities of ILD with no significant difference among ILDs subtypes, while ischemic heart disease as one of the comorbidities was significantly frequent with CTD-ILD.
Fifty two percent (52.9%) of HP cases had a normal CXR, while reticular CXR significantly found with CTD-ILD, reticulonodular opacities found with IIP diagnosis, and for unclassifiable group cystic pattern and reduced lung volume were significantly found.
On analysis, the HRCT pattern, we found that mixed pattern, GGO and reticulation were the most frequent pattern encountered with no significant difference among different ILD subtypes.
In addition, the distribution of abnormalities on HRCT weren’t significantly different among types of ILD.
COX regression analysis found that age > 50 years, female sex, residence in rural areas, BMI >25, professional occupations, housewifes and bird’s breeding were significant risk factors for ILDs.