الفهرس 
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Abstract
The master thesis include aim of the work and three main chapter
I- Aim of the work
the work aimed to prepare and characterize a new dihydrazone
ether ligand and its metal complexes aiming to
study their effects in the treatment of tumor diseases.
II- Introduction
This chapter includes an overview of previous researches for
complexes of di-hydrazone ligands and their application.
III- Experimental
This chapter contains the chemical and instruments used in
Practical part of thesis as follow:
1) Preparation of di-hydrazone ligand and its metal complexes.
2) characterization of the ligand and its complexes using:
Physical techniques such as molar conductance and magnetic
susceptibility
Elemental analyses (C, H, N, Cl and M).
Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra
and ESR measurements.
Thermal techniques as DTA. and TGA
3) Measurement of antitumor activity
iv. Results and discussion
This chapter includes characterization of the ligand and its complexes.
The ligand (E)-N’-(2-hydroxybenzylidene)-4-(4-(((E)-2-(2-
hydroxybenzylidene)hydrazinyl)oxy)phenoxy)benzohydrazide ( H2L)was
prepared as follow:
1- Condensation of parachlorophenol with of methoxy-para-hydroxy
benzoate sodium salt (1:1) for one hour to obtain methyl 4-(4-
hydroxyphenoxy)benzoate
2- Condensation of methyl 4-(4-hydroxyphenoxy)benzoate with
hydrazine hydrate for two hours (1:2) to obtain 4-(4-
hydrazinylphenoxy)benzohydrazide.
3- Condensation of 4-(4-hydrazinylphenoxy)benzohydrazide with
salicyaldehyde for 30 minutes (1:2) to obtain The ligand (H2L) (E)-
N’-(2-hydroxybenzylidene)-4-(4-(((E)-2-(2-
hydroxybenzylidene)hydrazinyl)oxy) phenoxy)benzohydrazide.
The reaction of the ligand (H2L) with Cu(II), Ni(II), Fe(III), Co(II),
Zn(II), Pb(II), Ca(II), Mg(II), AL(III), and Ba(II) complexes have been
synthesized and characterized by (1H-NMR, mass, IR, UV-VIS, ESR)
spectroscopy, (magnetic moments, conductance) measurements,
(elemental and thermal) analyses. The IR spectral data show that, the
Schiff base behaves as a neutral tetra dentate ligand bonded to the metal
ions through the azomethine nitrogen atom and oxygen atom in hydroxyl
group which protonated or deprotonated form adopting either octahedral
or tetragonally distorted octahedral geometries. Molar conductance in
DMF solution indicates that, the complexes are non-electrolytes. The
ESR spectra of solid of copper(II) complexes (8,9 and 11) are
characteristic of species d9 configuration having axial type of a d(x2-y2)
ground state which is the most common for copper(II) complexes.
However, Fe (III) complex (4), show isotropic type indicating an
English summary
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octahedral geometry. Cytotoxic evolution of the ligand and its complexes
have been carried out. Complexes show enhanced activity in comparison
to the parent ligand. Metal complexes (9), (13),(17) and (18) were
evaluated against HEPG-2 cell line showed better chemotherapeutic
effect against HEPG- 2 cell line than the standard drug used. Also, the
Cd(II) complex (17) shows the highest potency of inhibition at 500 μg/ml
against HEPG-2, compared with the standard drug.