الفهرس 
TaurineOnly 14 pages are availabe for public view
 |  | from | 237 |  |  |
| | | from | 237 | | |
Abstract
The present work was performed to investigate the effect of
taurine on depression associated with obesity and streptozotocin
induced diabetes in rats.
Sixty male albino rats of local strain were used in this
study; the rats were divided into six equal groups (ten rats each):
group 1 (Control group): received saline intraperitoneally as a
vehicle once a day for 30 days.
group 2 (Taurine group): received taurine (100 mg/kg)
intraperitoneally once a day for 30 days.
group 3 (STZ-diabetic group): Diabetes was induced by a single
dose of streptozotocin (50mg/kg) by intraperitoneal injection.
group 4 (Obese group): Obesity was induced by feeding rats with
high fatty (HF) diet for 8 weeks
group 5 (Taurine treated diabetic group): After induction of
diabetes, rats received taurine (100 mg/kg) intraperitoneally once a
day for 30 days.
group 6 (Taurine treated obese group): After induction of
obesity, rats received taurine (100 mg/kg) intraperitoneally once a
day for 30 days.
At the end of the experiment, Body mass index (BMI) was
determined and behavioral tests including Open field test (OFT)
and Forced swim test (FST) were done in all groups. Then, all rats
Summary & conclusion
163
were sacrificed to collect blood samples for estimation of the
following parameters:
-Fasting glucose level
-Serum insulin level
-HOMA IR
-Serum triglycerides level
-Serum LDL cholesterol lev.