الفهرس 
I: INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Cancer is one of the most serious disease cause millions of deaths worldwide per
year, and A number of affected persons and deaths are increasing steadily.The
development of new chemotherapeutic agents for the treatment of cancer is still
urgently needed to help to ensure the availability of new drug candidates to feed the
preclinical pipeline. This will help to surmount current issues arising from the
drawbacks of current drugs such as low efficacy, significant side effects and
resistance. In this context, plants are still an important resource for the discovery of
new drugs. Natural products have recently drawn renewed interests and attentions
as the seed of novel medicines. However, the availability of such natural products
from nature tends to be severely limited. In order to develop novel medicines from
natural products, sufficient amounts of compounds need to be provided for
derivatization and biological testing. One of the goals of our thesis is to establish
practical synthetic route for the natural products of medicinal importance. In
addition, a variety of derivatives of the natural products will be synthesized for
biological testing. Many naturally occurring compounds, including the minor alkaloid
neocryptolepine 1 and major alkaloid cryptolepine 2, were isolated from the roots of
the West African climbing shrubCryptolepis sanguinolenta (Figure 1), a traditional
herb used in folk medicine for the treatment of malaria.Both of the two tetracyclic
heteroaromatic compounds are linearly fused indoloquinolines and exhibit a wide
scope of biological activity. Therefore, we selected neocryptolepine 1 as the lead
compound for the development of a new drug because of its lower cytotoxic activity
compared to cryptolepine 2 towards the DNA intercalation in addition alkaloids are
known for their broad spectrum of pharmacological activity.