الفهرس 
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Abstract
This study aimed to investigate the effect of vitamine E on male and female rates treated with high fructose solution (15%) as a Metabolic Syndrome (MS) inducer.
Thirty-six rats (18 male+18 female) were randomizer in to three experiential groups (12 rates each: 6male & 6female) The first one served as control while the second group (experimental fructose group) was received solution of 15% fructose in drinking water for 8 weeks. The Third group (fructose+ vitamin E) received solution of 15% fructose in drinking water and the same food + 0.2mg vitamin E by oral gavage daily.
Some biochemical parameters and anthropometrical changes were determined and the main results can be summarized as follows:
1-Anthropometrical changes:
1-It was found that body weight significantly increased in all of the experimental groups during experimental period.
2-Body Math Index (BMI) was significantly decreased by adding Vitamine E in the diet of rats fed on high fructose diet.
3-Weights of liver and kidneys of rats fed high fructose diet (second group) was significantly increased compared to control group.
2-Biochemical Parameters:
1-It was noted that serum total Proteins ˒Albumin, fructose and glucose concentrations were significantly increased by (13.8-15-24.37-13.44%) respectively in male rates while these parameters were significantly increased in females by (10.48-21.37-14.5-6.61%) respectively in rates fed high fructose diet (second group) compared to control group.
2-Hepatic enzymes in both male and female rats fed high fructose diet (second group) were significantly elevated. In contrast enzymes activities were significantly reduced in rats fed high fructose diet + Vitamine E (third group).
3-Renal Function tests (uric acid and urea) were significantly increased in rats fed high fructose diet (second group) compared to the control group.
4- Total lipid concentration significantly increased in female rats fed on high fructose diet compared to male fed on high fructose diet.
5-High fructose diets induced metabolic syndrome in male and female rats which was observed by increasing in triglyceride & malondialdehyde concentrations, TBARS levels and by decreasing of HDL-C in relation to the control group.
6-Administration of vitamin E in rat diets fed high fructose diet significantly decreased MAD concentrations in relation to rats fed high fructose diet (second group).
In conclusion, this study demonstrated the impact of vitamin E on high fructose diet - induced metabolic syndrome in male and female rats. Vitamin E revealed attenuated effect against metabolic syndrome induced by high fructose diet. This was observed by significantly reduced in some anthropometrical and serum biochemical parameters in rats exposed to vitamin E.
Conclusively, these findings suggest that vitamin E can be used to reduce the metabolic syndrome in rats fed on high fructose diet. Further studied are needed to study metabolic syndrome induced by other doses of fructose and to what extent vitamin E can be reduced this metabolic syndrome.