الفهرس 
Chronic Kidney Disease (CKD)Only 14 pages are availabe for public view
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Abstract
This study aimed to evaluate serum level of resistin hormone in children with chronic renal failure with correlation with other clinical and laboratory parameters and the effect of HD on resistin level.
This study comprised:
1. Thirty four CRF patients under regular hemodialysis. They were 18 males and 16 females. Their ages ranged from 6 years to 18 years with mean of 13.7years.
2. Thirty CRF patients under regular conservative therapy. They were 18 males and 12 females. Their ages ranged from 6 years to 18 years with mean of 12.3 years.
3. Thirty two healthy children, acting as the control group. They were 18 males and 14 females. Their ages ranged from 6 years to 18 years with mean of 13.2 years.
All those children were subjected to detailed history, clinical examination and laboratory investigation(complete blood count ,Na, K, Ca, Ph, renal biopsy if needed , renal functions (serum creatinine and urea ), and serum resistin level).
from this study, we can conclude that the child would be more growth retarded as long as his renal functions were more impaired. This is evidenced by the lowest median values of height, weight and BMI in dialysis group which had the most impaired renal functions.
There were highly significant positive correlation between serum resistin and both creatinine and potassium levels and highly significant negative correlation between serum resistin to white blood cells count and platelet count. While there were a significant negative correlation between serum resistin and hemoglobin level and hemotocrit level and a significant positive correlation between serum resistin and age, pulse, systolic blood pressure, height and urea but non significant positive correlation between serum resistin and diastolic blood pressure, weight, red blood cells count, sodium level, calcium level and phosphorus level and non significant negative correlation between serum resistin and body mass index and duration of dialysis.
We can also conclude that median value of resistin was higher in CRF patients than in control group, and their levels is higher in HD group than in conservative group as supported by P value <0.001.
The median value of resistin in HD group after HD session was significantly lower than before HD session indicating that HD session could reduce the elevated levels of resistin but still not effective enough as post dialysis levels were still higher than conservative and control group.