الفهرس 
Introduction.Only 14 pages are availabe for public view
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Abstract
Although the impact of HLA compatibility has been recognized for two decades, the advances in immunosuppression protocols are such that rejection episodes are managed more efficiently, thus minimizing the importance of HLA matching. A study based on the United Network for Organ Sharing (UNOS) data reported that the impact of HLA compatibility had greatly diminished (Su et al., 2004).
Consequently, some allocation programs have gradually toned down the role of HLA matching from the algorithms used for prioritizations on the waiting list. The lower importance of HLA matching was also favored in the early years of the 21st century with the advent of the microarray-based luminex technology for detecting DSA, thus allowing organ allocation around well characterized HLA specificities (Laperrousaz et al., 2012).
However, the results of Opelz and Dohler on a large study cohort (135,970 kidney transplants) clearly showed that the significance of HLA matching on graft survival rate has not lost its importance, and this is obvious when comparing the decades 1985–1994 and 1995–2004. Even when analyzing the last five years of the study period separately (2000-2004), a significant correlation of graft survival with HLA matching was disclosed (Opelz and Dohler, 2007).
In addition to the classical HLA-A, -B and -DR antigens, the role of HLA-C and -DQ antigens in terms of graft survival or sensitization is now documented (Tran et al., 2011).
Analysis of the immunogenicity of incompatible HLA-A, -B antigens in terms of the numbers of amino acid residue mismatches (epitopes mismatches) is associated with better transplant outcome than conventional matching based on HLA typing by serology (Kosmoliaptsis et al., 2010).