الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Breast cancer is the most common type of cancer and the second leading cause of cancer-related death among women. It affects more than 1 million women worldwide.
Outcomes for breast cancer vary depending on the cancer type, extent of disease, and patient’s age. Early diagnosis and accurate follow-up of these patients are important for efficient patient management. In addition; early diagnosis of recurrent breast cancer is important for planning future therapeutic strategies which, if initiated without delay, aim either to cure or to prolong disease-free survival and to improve the quality of life of patients with cancer.
18F-FDG PET/CT-a new promising modality- which integrates functional and anatomic assessments has been introduced in the diagnosis of breast cancer. Its diagnostic value is based on the detection of metabolic changes preceding structural findings.
Our aim was to study the accuracy of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) scan in diagnosis of primary and loco regional recurrent breast masses compared with histopathological results and to correlate the results of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) with histopathological findings in breast carcinoma patients.
This study included 24 female patients diagnosed with primary or loco-regionally recurrent breast cancer who were presented to radiology department in Ain Shams University Hospitals in the duration between June 2017 and June 2018.
Our study revealed the following results; FDG uptake is significantly higher in invasive ductal than invasive lobular breast carcinoma (P < 0. 001). Also, a positive correlation is seen when correlating the SUVmax tumor of the lesion with the histological grade (P =0.010, odds ratio =10.154). In addition, a positive correlation is observed when correlating the SUVmax tumor of the lesion with the size whether in the breast or the lymph nodes (P= 0.009 in breast lesions and P= 0.012 in lymph nodes, Odds ratio=20.344). An even stronger positive correlation is observed when correlating the tumor to liver ratio (TLR) and the tumor histological grade (P =0.005) and tumor size. (P=0.000). However, No relation was found between high SUVmax of the tumor and presence of metastasis.
In conclusion, measuring 18F-FDG uptake may be of value that aids in identifying the histological and morphological characteristics of the tumor affecting the treatment strategy, prognosis and survival rate of the disease and should be considered on the prognostic parameters of breast cancer.
The study recommends that despite the fact that 18F-FDG PET/CT is widely used for evaluation of breast cancer, until recently it can’t replace other diagnostic modalities so the patient must undergo other diagnostic tests as MRI and sonomammography for full evaluation of the condition. Also, SUVmax and tumor to liver ratio (TLR) may have a promising benefit in interpretation of size, type and grade of the tumor, thus may play a role in predicting the prognosis of the disease. However the study needs to be extended to combine clinical and imaging parameters for attaining better health care for breast cancer patients.