الفهرس 
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Abstract
Summary
In this study 40 colectomy samples from patients who were known to have colorectal adenocarcinoma were studied for CD44 immunohistochemical expression and also Alcian Blue staining at PH 2.5 to detect the presence of acidic mucin.
Mean age of cases was about 55 years. Males were slightly more predominant (57.5%), 40% of cases located in the right colon and 62.5% were more than 5 cm in their maximum diameter. The majority of the cases were diagnosed as adenocarcinoma (90%) and more than 80% were moderately differentiated.
Alcian Blue staining was positive in 65% of the cases (45% of cases positive focal staining and 20% of cases positive diffuse staining). Alcian Blue staining status was significantly higher in the mucinous adenocarcinoma. Alcian blue staining is significantly related to the lymph node status as by increasing lymph nodes involvement the alcian blue staining was significantly decreased. There was also significant relation between AB staining and absence of distant metastasis. With increased tumor TNM staging group, alcian blue staining status was significantly more negative.
CD44 expression was positive in 75% of the included colorectal adenocarcinoma cases. Positive group was divided into three categories (22.5% in +1 score, 32.5% in +2 score and 20% +3 score (. The expression of CD44 was significantly related to the lymph node status (N) as by increasing lymph nodes involvement the expression of CD44 is increased. The CD 44 expression status was significantly more positive in higher TNM staging group. No significant difference was found as regarding patients’ age, sex, tumor size, location, grade and the histological type.
There was a moderate negative correlation between the CD44 expression and Alcian blue staining.