الفهرس 
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Abstract
Summary
There is a great need for identification of biomarkers that could help in the diagnosis and the prediction of early cases of osteoarthritis (OA) being the most common chronic, degenerative joint disease nowadays causing disability. We undertook this study to determine whether circulating levels of interleukin-6 (IL-6) can serve as useful biomarker in OA and to explore the potential associations between IL-6 in serum and the progression of the disease.
Data were obtained from the cohort study of 60 subjects from the outpatient clinic of Rheumatology and Rehabilitation department, faculty of medicine, Beni-Suef university. The disease activity status of the patients was assessed using the Western Ontario and Mcmaster Universities Osteoarthritis Index (WOMAC), the degree of disability was assessed by the Modified Health Assessment Questionnaire disability index (M.HAQ) and the radiological assessment of the diseased joint was obtained by Kellgren and Lawrence (K-L) grade. Concentrations of IL-6 were measured by ELISA. Cases had significant higher levels of IL-6 levels than controls (P-value<0.001), which confirms the contribution of IL-6 in the pathogenesis of osteoarthritis and its potential usage as an inflammatory biomarker to help in the diagnosis of the disease. IL-6 was significantly positively correlated with WOMAC, M.HAQ, K-L scores, ESR and CRP.
Cases with severe M.HAQ scores had significant higher mean IL-6 than who had moderate score (P-value: 0.003) confirming the contribution of IL-6 in the pathogenesis and degree of disability caused by the disease, so it can be used for following up the disease. By using ROC curve, at a cut-off value of 38 the sensitivity of IL-6 for presence of early stages osteoarthritis was 45.5% and the specificity was 14% (AUC=0.113) which illustrate the potential usage of IL-6 as predictors of early stages of osteoarthritis activity.
Cases with severe WOMAC scores had significant higher mean IL-6 than who had moderate score (P-value: 0.002) which confirms the contribution of IL-6 in the pathogenesis and degree of severity of the disease, so it can be used for following up the disease. By using ROC curve, at a cut-off value of 41.7 the sensitivity of IL-6 for presence of early stages osteoarthritis was 64% and the specificity was 20% (AUC=0.324).
Cases with severe K-L scores had significant higher IL-6 level than who had mild score (P-value<0.001) confirming the role of IL-6 in degree of radiological severity of the disease. By using ROC curve, at a cut-off value of 41.7 the sensitivity of IL-6 for presence of early stages osteoarthritis was 64% and the specificity was 20% (AUC=0.324).
Higher examinated concentrations of IL-6 were associated with OA patients so it is correlated with increased risk for OA, so it can be used as a biomarker for disease diagnosis. Higher levels of IL-6 in correlation with disease activity and disability means that it can predict the progression of the disease.