الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The present thesis comprises the following chapters:
Chapter I (Introduction):
An introductory part describing the chemistry of spiroimidazolidinediones , different approaches for its synthesis and aldose reductase inhibitors as targeted hypoglycemic agents.such as glibenclamide and repaglinide.
Chapter II (Research Objectives):
The synthetic routes for the preparation of target compounds were illustrated by 5 schemes.
Chapter III (Theoretical Discussion):
A theoretical discussion of synthetic pathways that were developed to obtain the final new compounds and their mechanisms, spectral data, biological results and molecular modeling.
Chapter IV (Experimental):
The present investigation involves the synthesis of 7 intermediates. In addition to, the synthesis and characterization of the following 22 compounds.
Chapter V (Conclusion):
A summary of the present study, conclusions and the future work.
Chapter VI (References):
A list of references which were used and their arrangement according to their order in the thesis.