الفهرس 
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Abstract
Vitiligo is a common skin disease with unknown etiology. It is a multifactorial disorder that may involve genes expressed in melanocytes and several theories have been proposed about the pathogenesis of vitiligo.
The psychological impact of vitiligo on the quality of life can be disastrous, as dissatisfaction with body image can smother self-esteem and develop a depressive state, especially among dark or tan-skinned patients.
The study aimed to improve the diagnosis and management of vitiligo in male patients.
The objectives were to determine Estrogen receptor gene polymorphism in male vitiligo patients and to correlate Estrogen receptor gene polymorphism with the disease occurrence and severity.
This is a case-control observational study conducted on 90 males divided into two groups, one group was 45 healthy males as a control group and the other group was 45 vitiligo male patients with vitiligo at the Dermatology Clinic of Suez Canal University Hospital, Ismailia, Egypt. Both groups underwent complete history taking and clinical examination. Both groups asked to donate a blood sample to assess estrogen receptor alpha gene polymorphism.