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Abstract Summary and conclusion Diabetic macular ischemia (DMI) is a condition that didn’t receive enough attention despite its important impact. The presence of DMI in the context of diabetic retinopathy and maculopathy affects visual acuity and changes management decisions. FFA is – so far - the gold standard for diagnosis and grading of DMI, It was used in this study as a method of patients enrollment. However, FFA has its hazards and drawbacks especially being invasive, non-repeatable, difficult Data quantification and that associated leakage can obscure the presence of ischemia. OCTA avoids many of these hazards and drawbacks, despite having its own ones, especially its artifacts and the relatively smaller field of view. It has the ability to detect DMI and its findings can be quantified. This study was a cross sectional study that enrolled patients diagnosed with DMI using FFA (20 eyes), then the findings of their OCT and OCTA images were examined, analyzed for correlation. In addition to this group of patients, the study also involved a smaller group of normal eyes (10 eyes) as a control group. In this study, OCTA was able to detect macular ischemia in all the enrolled patients and in some cases macular ischemia was more evident on OCTA imaging but the study didn’t try to compare OCTA to FFA. The two OCTA parameters that were used in this study to evaluate the degree of macular perfusion (FAZ area and VAD for both SCP and DCP) were found to have a statistically significant difference |