الفهرس 
Introduction And Aim Of The WorkOnly 14 pages are availabe for public view
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Abstract
This prospective randomized study was conducted in El-Minia University Hospital during the period from March 2017 to December 2017. A total of 60 adult ASA grade I and II patients of female patients, aged (18 – 40) years old scheduled to undergo elective cesarean section under spinal anesthesia were included in the study.
This study was conducted to compare the effect of pregabalin and paracetamol on duration of spinal anesthesia and reduction of early postoperative pain when taken orally preoperative.
Anesthetic technique was standardized in all the groups. Patients were randomly allocated into two groups each contained 30 patient, two hours preoperative group (I) receive 150 mg of oral pregabalin and group (II) receive 500 mg of oral paracetamol.
The following variables (SBP, DBP,MAP, HR) were recorded just preoperative and at 5 & 10 & 15 & 20 & 25 & 30 & 45 & 60 & 75 minutes intraoperative and time to T10 sensory block , time to maximum sensory block and time to motor block up to Bromage 4. Also time to 2 segment regression, time to regression for bromage 1, time for first analgesic request, VAS at 6th & 24th hours postoperative and number of analgesic doses consumed. Adverse effects such as nausea, vomiting, dizziness, drowsiness were reported and compared between both groups.
We found that (SBP, DBP, MAP and HR) did not differ significantly between groups, time for initial motor and sensory block was significantly shorter in group (I). Time for 2 segment regressions, time for regression to bromage 1 and time for first analgesic request was significantly longer in group
(I). VAS at 6th and 24th hours postoperative and number of analgesic doses comsumed were lower in group (I) .
• Regarding adverse effects occurred during study period, no adverse effects were detected in both groups e.g nausea , vomiting , dizziness , drowsiness.
We concluded that oral pregabalin in a single dose of 150 mg , given two hours preoperative is an effective mean for prolonging duration of spinal anesthesia for cesarean section and reduce early postoperative pain better than paracetamol when used orally two hours preoperative in a dose of 500 mg .