الفهرس 
Precursors of prostatic adenocarcinomaOnly 14 pages are availabe for public view
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Abstract
Prostate cancer is the sixth most common cancer in the world.
Considering the limitations of traditional tests as serum PSA level, it seems important to study novel putative biomarkers for prostate cancer diagnosis and progression.
It is sometimes difficult to reach firm diagnosis of prostatic adenocarcinoma especially for small foci of carcinoma in needle biopsy. Moreover, many benign prostatic lesions can mimic prostatic adenocarcinoma. Therefore, the application of immunohistochemistry to distinguish prostate carcinoma from its mimickers and to confirm the diagnosis would be helpful and necessary.
The aim of the current work was to study the immunohistochemical expression of STEAP1, D2-40 and P63 in the available variants of prostatic adenocarcinoma, HGPIN and benign epithelial lesions of prostate stressing on the role of these markers in
differentiating prostatic adenocarcinoma from its benign mimickers and HGPIN and to correlate the expression of STEAP1 with prognostic parameters of prostatic adenocarcinoma as Gleason score.
The present work included 78 cases of prostatic lesions consisting of 30 cases of benign prostatic lesions (38.5%), 8 cases of HGPIN
(10.3%) and 40 cases of prostatic adenocarcinoma (51.2%).