الفهرس 
Chapter I: Introduction and literature reviewOnly 14 pages are availabe for public view
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Abstract
Anastatica hierochuntica L. (Cruciferae) has been known in Egyptian folk medicine as
antiparasitic and anticancer agent as well as remedy for gastrointestinal disorders, diabetes and
heart diseases. Despite the wide usage, A.hierochuntica research provides insufficient data to back
up its traditional practice. The antischistosomal activity and anticancer activity of A.hierochuntica
70% methanol extract were investigated. Invitro antischistosomal activity was evaluated after the
incubation of Schistosoma mansoni adult coupled worms with different doses of extract and the
motility was monitored by inverted microscope. The selective targeting of cancerous cells versus
the safety on non-cancerous cells in addition to the phytochemical identification of bio-active
compounds via 1H-NMR and LC-ESI-MS were demonstrated. As a result, A. hierochuntica crude
extract (3.0 μg/ml) caused (96.3±6.41%) of male adult parasites mortality, non-significant
cytotoxicity on isolated NHPL and exerted cytotoxicity (73.0±4.12%) on AML cells. These
selective anticancer properties were immunocytochemically confirmed as mitochondrial p53-
independent cell death pathway.