الفهرس 
Chapter I Introduction :Only 14 pages are availabe for public view
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Abstract
I- Aim of the work The work aimed to prepare and characterize new Thiosemicarbazone ligand and its metal complexes aiming to study their effects in the treatment of tumor diseases.
II- Introduction This chapter includes an overview of previous researches for complexes of hydrazone ligands and their application.
III- Experimental This chapter contains the used chemical and instruments in
Practical part of thesis as follow:
1) Preparation of Thiosemicarbazone ligand and its metal complexes.
2) characterization of the ligand and its complexes using:
Physical techniques such as molar conductance and magnetic susceptibility
Elemental analysis (C, H, N, Cl and M).
Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra and ESR measurements.
Thermal techniques as DTA. and TGA.
3) Measurement of antitumor activity iv. Results and discussion
This chapter includes characterization of the ligand and its complexes. The ligand (1Z,6Z)-diethylN’1,N’6-dicarbamothioyl-2-((E)-1-(2-carbamothioylhydrazono)ethyl)5((Z)-1-(2carbamothioylhydrazono)ethyl) hexanebis(hydrazonate) was prepared as follow:
1- Condensation of dibromoethane with of ethylacetoacetate (1:2) for one hour to obtain diethyl 2,5-diacetylhexanedioate.
2- Condensation of diethyl 2,5-diacetylhexanedioate with of thiosemicarbazone for two hours (1:4) to obtain (1Z,6Z)-diethylN’1,N’6dicarbamothioyl2((E)1(2carbamothioylhydrazono)ethyl)5((Z)1(2carbamothioylhydrazono)ethyl) (H4L)
The reaction of the ligand (H4L) with Cu(II), Ni(II), Fe(III), Co(II), Zn(II), Cd(II), Pb(II), Sr(II), Mg(II), AL(III), Ag(I), and Ba(II) complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS, ESR) spectroscopy, (magnetic moments, conductance) measurements, (elemental and thermal) analysis. The IR spectral data show that, the Schiff base behaves as a neutral tetra dentate ligand bonded to the metal ions through the azomethine nitrogen atom and Sulphur atom in thiocarbonyl group which protonated or deprotonated form adopting either octahedral or tetragonally distorted octahedral geometries. Molar conductance in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid Cu (II) complexes (2, 9, 10, &14) show an axial type indicating a d(X2-y2) or d(Z2) ground state with a significant covalent bond character. However, Co (II) complexes (3&13), and Fe (III) complex (16), show isotropic type indicating an octahedral geometry. Cytotoxic evolution of the ligand and its complexes have been carried out. Complexes show enhanced activity in comparison to the parent ligand. Metal complexes (4), (7), (9), and (19) were evaluated against HEPG-2 cell line showed better chemotherapeutic effect against HEPG- 2 cell line than the standard drug used. Also, the Cu(II) complex (9) shows the highest potency of inhibition at 50 μg/ml against HEPG-2, compared with the standard drug.