الفهرس 
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Abstract
Respiratory diseases are a common and significant cause of illness and death around the world. A lung infection indicates pathological conditions affecting the lung tissue. Acute lung injury (ALI) is a major cause of morbidity and mortality in humans and animals. chronic lung injury (CLI) may refer to: Asthma, broncho-pulmonary dysplasia and chronic obstructive pulmonary disease. These conditions are currently global health problems with a major economic and social impact. In traditional and modern medicines, Nigella sativa extract, thymoquinone (TQ) has several benefits. Here, we examined the role of crude and Nano TQ on experimentally induced ALI and CLI by Lipopolysaccharide (LPS) via some parameters evaluation as gross and microscopic lung lesion score, inflammatory cytokines analysis beside immunohistochemical and ultrastructural changes.
First experiment (ALI) conducted on 40 male albino rats equally divided in to 4 groups: group 1 (LPS) each rat was installated i.t by single dose (200µg LPS/rat). group 2 (TQ +LPS) each rat was i.p injected daily by TQ for 7 days 1mg /rat prior LPS installation. group 3 (TQ only) each rat was i.p injected daily by TQ for 7 days 1mg /rat. group 4 (Control-DMSO) each rat was i.p injected daily by DMSO 5% for 7 days 1mg /rat. Lung specimens collected from sacrificed rats at 12h and 24h post LPS installation were subjected to histopathology, TEM and IHC for activated NF-κB. ELISA for serum levels of IL1ᵦ and TNFα was also done.