الفهرس 
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Abstract
Results of the sequence analysis between the different isolates (51 samples) that were found in Cairo, Mansoura (Lower Egypt) and Asiut (Upper Egypt), were compared and found that there was a great similarity between the different isolates especially between Asiut and Mansoura isolates and confirmed by phylogenetic tree. The sequences of 14 families in Mansoura, Cairo and Asiut were also analyzed and comparative work was done for isolates within the same family and it was revealed that in the same family there is a high genetic similarity between them in the same nucleotide sequence with the same genotype. There were fourteen family members with index either father or mother and that index had one contact or two contacts who can acquire the infection from the index .The father index (number =10 ) with 71.4% and mother index (number =4) with 28.6% , in case of the index father had number of house hold contacts equals 16 individuals with 76.2% and these contacts were: Mother who is in direct contact with her spouse and in a risk of HCV transmission through wounds , sharing of personal hygiene items and the percent of HCV transmission from father to mother is 37.5%. The second contact in the family is son that is also in a direct contact with his father and in a high risk of HCV transmission through different routes either through razor blades, or using his personal hygiene items and the percent in this case is 37.5%. The third house hold contact is his daughter who is subjected directly to HCV infection either through blood transfusion or using tooth brush or using his nail clipper and this represents 25% of HCV transmission. On the other hand, in case of the index mother that had number of contacts were 5 individuals with 23.8% and these house hold contacts were: father that is under high rates of HCV transmission from his spouse (wife) that can transmit the disease through sharing of personal hygiene items or through sexual contact and this represents 40% and this percent isn’t low so there is high evidence for intrafamilial transmission. The second contact is son, that is subjected for infection but not the same of his sister as son may acquire the infection from his mother through using her tooth brush or nail clippers and his percent represent 20%. The third house hold contact is her daughter that is subjected highly to HCV infection as daughter is usually in contact with her mother through different routes either sharing her personal items, nail clippers or through wounds or needles of syringes and has high risk for HCV transmission and percent of transmission from mother to her daughter is 40% . Our current study adds that intrafamilial transmission occurs not only in genotypes but also in subtypes in the same sequence. All of this summarizes that the different HCV genotypes rates and subtypes were transmit highly with its same nucleotide sequences in the same family among the contagious either mother or father and their contacts either son or daughter depending on the mode of transmission in the family and support the finding that intrafamilial transmission of HCV does occur.