الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Atherosclerosis is a chronic inflammatory response of the arterial wall to endothelial injury and the inflammation cascade 198.
Chemerin was defined as an adipocytokine with pro-inflammatory actions, and accepted as being a strong marker because the serum chemerin levels are increased in a CAD condition 1.
Positive correlations were found with arterial stiffness and coronary arterial plaques in cross-sectional studies 188,212, 213.
Atherosclerosis is among other conditions that have relationships with chemerin on multiple epidemiologic levels 201, 202. This is due to receptors on macrophages 161,203 and the activity of chemerin in the inflammatory cascade 167.
The relationship between chemerin and the cardiovascular system could not be shown primarily, but its secondary effects were evaluated: as a chemokine, chemerin allows for chemo-attraction through the vasculature 161, changes endothelial adhesion levels 189, and is extracellularly activated in the lumen 161; as an adipokinine, chemerin adjusts lipid 200 and glucose levels (through glucose intolerance) 171, possibly altering their infiltration into endothelium; and as a growth factor, it promotes micro-vessel growth to support adipocytes 176. Changes in endothelial adhesion levels, adipokinine effect on adipose tissue 200 and effects on glucose Levels 171 are several of these effects.
The purpose of this study was to evaluate serum levels of chemerin in patients as regard to presence and/ or absence of CAD and its influence on chemerin levels.
88 individuals were enrolled, divided into 4 groups:
group I (n=21): CAD and diabetic patients.
group II (n=30): CAD and non diabetic patients.
group III (n=12): Diabetic and non CAD Patients.
group IV (n=25): Non CAD and non diabetic subjects.
Participants in the study were subjected to full history taking, thorough clinical examination and 12 lead ECG.
Lab investigations were done in the form of serum creatinine and urea levels, hemoglobin level, fasting blood sugar, PPBS, lipid profile (TC, LDL, HDL and TG) and serum chemerin levels in all subjects underwent coronary angiography.
2D echocardiography, M-mode were performed; LV dimensions were measured including LVEDD, LVESD, IVS, LVPW, LVMI,RWT,LA,PASP and left ventricular ejection fraction.
The severity of CAD was determined using the Gensini score and vessel score (number of vessel affected).