الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a chronic, non-infectious disease that can involve the skin, nails, joints and is associated with a number of comorbidities as cardiovascular disorders, diabetes, metabolic syndrome and depression. Psoriasis is a disfiguring and disabling in severe cases with impact on patient psychology and affecting patients quality of life. The etiology remains unclear and treatment is still mostly based on combating acute symptoms. TLR gene polymorphisms have been widely evaluated in the several inflammatory diseases including rheumatoid arthritis and seronegative spondyloarthropathies inflammatory diseases (Bogaczewicz et al., 2013). TLR9 gene is located in chromosome 3p21.3. TLR9 works as a gatekeeper against infection because it recognizes CpG sequences of microbial DNA that are rare in DNA from vertebrate cells. It has been found on the surface of many cells, including monocytes, dendritic cells, natural in relation to killer cells, and B lymphocytes. The activation of TLR9 prompts an inflammatory pathway mainly driven by interferon and interleukin. Collection of samples: 3 ml. of venous blood sample was be taken from each patient and control The gene polymorphisms were analyzed using the amplification refractory mutation system polymerase chain reaction method (ARMSPCR). The study group consisted of 50 unrelated patients with psoriasis vulgaris and 50 healthy volunteers. The mean Psoriasis Area Severity Index (PASI) was 13.6. In the study group there were 24 (49%) patients with early onset (< 40 years) and 26 with late onset psoriasis (≥ 40 years). The main age of our patient was 41.8±16.2. Other previous reports also reported psoriasis in the same age group In this study, male to female ratio is 1:1.3. In the current work, there was no statistically significant association between genotype for TLR9 polymorphism in studied cases regarding to clinical type of psoriasis, there was no statistically significant association between (PASI) and TLR9 polymorphism in studied cases. The presence of allele GG in TLR9 polymorphism was statistically more frequent in the group with late onset psoriasis in comparison with early onset psoriasis (73.08 % vs. 20.83%; p =0. 000221). The presence of positive family history was statistically more in the group of early onset psoriasis (%70.83 %34.62 % vs%; p = 0.0104) and the negative family history was statistically more in the group of late onset psoriasis (%65.38 % vs. 37.50 %; p = 0.0486). The presence of allele AG in TLR9 polymorphism was statistically more frequent in the group with early onset psoriasis in comparison with control (70.83% vs. 34%; p =0.0029) and their presence increases the risk of the development of this type of the disease.