الفهرس 
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Abstract
Beta-thalassemia are a group of hereditary blood disorders
characterized by impair production of the beta-globin chains of
hemoglobin resulting in variable phenotypes ranging from severe anemia
to clinically asymptomatic individuals.
Three main forms have been described: Thalassemia Major, variably
referred to as “Cooley’s Anemia” and “Mediterranean Anemia”,
Thalassemia Intermedia and Thalassemia Minor also called “Betathalassemia
carrier, ‘Beta-thalassemia trait’, or ‘heterozygous Betathalassemia.
Beta-Thalassemia is a significant public health problem in Egypt,
where over one million newborns are expected to be affected with this
disorder, and it is considered the most common genetically determined
chronic hemolytic anemia (85.1 %) in our locality. A high frequency of
carriers has been reported in Egypt, ranging from 4 to 10 %. This is due
to high rate of consanguineous marriage, which helps to accumulate
deleterious genes in Egyptian families.
Although Beta-thalassemia is a hereditary haemoglobinopathy
caused by defective hemoglobin Beta-globin synthesis , leading to excess
alpha-globin chains that cause hemolysis and impairment of
erythropoiesis, inflammation is known to play an important role in the
development of complication of the disease .Though higher standards of
care in Beta-thalassemia patients including blood transfusions combined
with adequate chelation therapy have led to enhance years of survival but
stimulant the rate of its related complication such as cardiovascular
disease (CVD) and arterial and venous thrombo-embolic events increased also. The underlying mechanisms of Beta-thalassemia related
complications were not determined clearly.
Adipose tissue is one of the most important endocrine and secretory
organs that release adipocytokines like adiponectin (resistin). Achronic
inflammatory state is present in Beta-thalassemia patients, with increased
levels of inflammatory cytokines.
Adipocytokines are considered important players in the
aetiopathogenesis of numerous metabolic, vascular and inflammatory
disorders.
Among these cytokines, much attention has been paid to
adiponectin, which has significant effects on the inflammatory process
Adiponectin attenuates inflammation, oxidative stress, and cytokine
production. Resistin is a member of the resistin-like molecule family of
cysteine-rich secretory 12-kDa proteins. Some studies have shown the
causative association between resistin and systemic inflammation,
especially in the vascular endothelium.
So, the aim of our study was to analyze adipocytokine
concentrations (resistin) in the different types of Beta-thalassemia
patients (major intermedia) and determine any possible correlations
with disease severity.
The present study was conducted on 90 subjects that classified into
three groups, group I and II: including 50 and 20 Beta thalassemia
patients (major intermedia) diagnosed by both clinical and laboratory
criteria and groupI: including 20 healthy individuals volunteer subjects
of matched age and sex (control group). All subjects were selected from
the hematology pediatric department, Menoufia university, Egypt from
the period of February 2016 February 2017. Clinical and laboratory data
of the studied groups were tabulated and statistically analyzed.