الفهرس 
Contentsيوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Preeclampsia, a hypertensive disorder of pregnancy, is associated with oxidative stress, hyperlipidemia, obesity, hypertension, diabetes, and polycystic ovarian diseases. The aim of this work was to evaluate the visfatin and human beta defensin-1 gene expression levels in placental hypertensive pregnant women groups (gestational, mild, severe and superimposed preeclampsia) compared to normotensive pregnant women. Some antioxidant parameters such as serum catalase activity, serum total antioxidant capacity level, blood reduced glutathione level and serum malondialdhyde levels were determined in all groups. For this purpose, the study group was comprised 80 Egyptian patients of newly diagnosed pregnant hypertensive disorder. Patients were divided into four groups. The first group was gestational hypertensive pregnant women (n=20). The second group was mild preeclampsia pregnant women (n=16). The third group was severe preeclampsia pregnant women (n=25). The fourth group was chronic hypertension with superimposed preeclampsia pregnant women (n=19). The normotensive pregnant women were comprised 10 normal unrelated subjects of matched age and with no family history of the disease. Results: we found decreased in visfatin and HBD-1 gene expression, catalase activity, reduced glutathione level and total antioxidant capacity level in gestational hypertension (non-significant), mild preeclampsia (significant), severe preeclampsia and superimposed preeclampsia (highly significant) compared to normotensive women. On the other hand, elevation of lipid peroxidation products (MDA) was observed in gestational hypertension (non-significant), mild preeclampsia (significant), severe preeclampsia and superimposed preeclampsia (highly significant) compared to healthy pregnant ones. Conclusion: visfatin gene expression has an important role in pathogenesis of preeclampsia and HBD-1 gene may be a regulator of blood pressure and provides a new therapeutic target for the treatment of hypertension. Our observation revealed that an imbalance between lipid peroxidation and antioxidants in preeclampsia lead to free radical mediated endothelial dysfunction.