الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Acne vulgaris is a multifactorial skin disease. A potential role for various growth factors such as insulinlike growth factor-1 (IGF-1) has been suggested in the pathogenesis of acne. Several studies have shown that elevated levels of serum IGF-1correlate with overproduction of sebum and acne. Objective: Measurment of the serum level of IGF-1 in acne patients in comparison to normal controls, and evaluate the relationship of these levels to severity of acne, in order to investigate the role of this factor in the pathogenesis of acne. Patients and Methods: Fifty-four acne patients and 14 healthy controls were subjected to detailed history taking, clinical assessment of acne severity was performed for patients. Body mass index was calculated and serum samples were collected from patients and controls for estimation of laboratory parameter (IGF-1 level). |