الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The aim of this work was to evaluate the role of magnetic resonance susceptibility perfusion in the differentiation between recurrent brain tumors and radiation necrosis.
The study included twenty patients with suspicious lesions of tumor recurrence or radiation necrosis on conventional MRI imaging studies.
All patients underwent conventional MR study and dynamic susceptibility contrast (DSC) perfusion MRI examination. Using an independent computer workstation, cerebral blood volume color map and T2* signal intensity time curves were generated and the hemodynamic parameters including the cerebral blood volume (CBV) and peak height (PH) were calculated, then normalized to the contralateral normal-appearing white matter (NAWM) to yield the relative CBV and relative PH.
Fifteen lesions (75%) out of twenty showed to be due to tumor recurrence, five of which were proven by histopathology, while the remaining ten were diagnosed by follow up MRI based on RANO criteria with average follow up of about 6 months. On the other hand, the remaining 5 lesions (15%) were diagnosed as radiation necrosis by prolonged follow-up MRI for 12 months, based on RANO criteria.
In our study, nearly all the recurrent lesions were hyperperfused in comparison to the contralateral NAWM with increased hemodynamic parameters namely the rCBV and rPH with the exception of one case which showed hypoperfusion pattern, while all the radiation necrosis/ pseudoprogression cases were hypoperfused with decreased rCBV and rPH.