الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 168 |  |  |
| | | from | 168 | | |
Abstract
Neonatal asphyxia is still one of the most important causes of mortality and morbidity in the neonatal period. Diagnosis of DIC whichis one of life threating complications for asphyxiated neonates is very difficult as the early signs may be subtle and different at different gestational ages, in addition. The diagnosis of DIC based onFDPs is usually delayed. The need is for an infallible test or combination of tests that are easily performed and quick availability of reports that can identify suspected infants at the time of initial assessment. Fibrinogen/CRP ratio is greatly important to detect overt and non overt DIC. The aim of the study isto detect overt and non overt DIC in neonates with moderate and severe asphyxia, our study was conducted on 50 neonates: 28 neonates with moderate asphyxia, 22 neonates with severe asphyxia according to Sarant staging.
All babies were subjected to:
1. History Taking: which included pre-natal history, natal history, post natal).
2. Clinical examination :which included (general, local examination).
3. Laboratory investigations: which included (CBC ,CRP, blood glucose, ALT, AST, urea, creatinine and serum electrolytes as Na+, K+ , Ca++, PT,PTT,D-dimer and plasma fibrinogen level.
4. ITSH scoring system.
Our work showed that there was highly significant increase in CRP level in severely asphyxiated group with mean (5.15±1.48 mg /dl) compared to moderately asphyxiated group (3.41±1.33 mg/dl) and the difference was statistically highly significant (p value < 0.001).
Summary
127
There was highly significant increase in D-dimer level in severely asphyxiated group with mean (4.76±1.73 ug/ml) compared to moderately asphyxiated group (2.93±1.79ug/ml)and the difference was statistically highly significant (p value < 0.001).
Also, there was significant difference as regarding to DIC score between the two studied groups.DIC score was significantly higher in severely asphyxiated neonates.
We found that there was significant difference as regarding to the incidence of overt and non-overt DIC between the two studied groups. Neonates with non-overt DIC were more in moderately asphyxiated group.
This study showed that the cutoff point for DIC score had the best sensitivity of (95%), specificity (97%) and accuracy (96%) at the (≥4.5 ) to predict death among overt and non overt DIC cases.
We found that there was highly significant decrease in fibrinogen/CRP ratio in severely asphyxiated group with mean (61.35±26.64) compared to moderately asphyxiated group (89.99±21.61) and the difference was statistically highly significant (p value < 0.001).
There was positive correlation between fibrinogen and CRP. There was negative correlation between fibrinogen/CRP ratio with D- dimer. There was positive correlation between fibrinogen/CRP ratio with plateles.
In this study, there was positive correlation between DIC score with weight.