الفهرس | Only 14 pages are availabe for public view |
Abstract Atrial Fibrillation (AF) is a supraventricular tachyarrhythmia characterized by uncoordinated atrial activation with consequent deterioration of atrial mechanical function,it is the most common sustained cardiac rhythm disturbance. Aetiology of atrial fibrillation consists of genetic factors (Both short and long QT syndromes, Brugada, hypertrophic cardiomyopathy and abnormal LV hypertrophy associated with mutations in the PRKAG gene.) and other factors including inflammation, autonomic nervous system activity, atrial ischemia, atrial dilation, anisotropic conduction, and structural changes associated with aging. Classification of AF Paroxysmal: Self terminating episodes (typically hours or days) Persistent: AF does not terminate by itself; however, after cardioversion sinus rhythm can be established Permanent (chronic): AF does not terminate, and, even after cardioversion, AF reoccurs quickly. Secondary AF that occurs in the setting of acute MI, cardiac surgery, pericarditis, myocarditis, hyperthyroidism, pulmonary embolism, pneumonia, or other acute pulmonary disease is considered separately. Lone AF generally applies to young individuals (under 60 years of age) without clinical or ECG evidence of cardiopulmonary disease, including hypertension. *Thromboembolism is a consequence of AF. The 3 major treatment strategies for AF are maintenance of sinus rhythm, heart rate control during AF, and prevention of stroke. |