الفهرس 
Epidemiology of bladder carcinomaOnly 14 pages are availabe for public view
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Abstract
Bladder cancer (BC) is one of the most common urogenital cancers; it ranks ninth in worldwide cancer incidence, fourth commonest cancer in men and 12th in women. In Egypt, it represents the third most common malignancy as it accounts for 8.7 % of total malignancies in both sex according to National cancer registry, 2014.
The aim of this study is to evaluate the immunohistochemical expression of SATB1, DACH1 and Vimentin to explore the role of epithelial mesenchymal transition (EMT) mechanism in the development and progression of bladder cancer in Egyptian patients with correlation to clinicopathologic and prognostic parameters.
Using the standard IHC technique, we assessed SATB1 and DACH1 expressions in 90 bladder carcinoma (80 primary and 10 metastatic) and 10 normal bladder urothelium specimens (control group). The 80 primary bladder carcinoma cases including; 50 radical cystectomies (muscle invasive bladder cancer) and 30 cold cup biopsies (Non muscle invasive bladder cancer). The cases were retrieved from the archives of Pathology Department, Faculty of Medicine, Menoufia University spanning the period between January 2014 and December 2016.
In current study, 72 cases of 80 studied primary bladder carcinoma cases were males (90%) and 8 were females (10%) with a male to female ratio of 9:1. The age ranged from 45 to 96 years with a mean of 62.2 years. 90% of our primary bladder carcinoma cases had tumor size ≥ 3 cm. Regarding bilharzial infection, 32.5% of our cases were associated with bilharziasis.