Author: Abd El-Samii, Basma Ataf Abd El-Ghafour./ Title: Role of Inflammation in Pentylenetetrazole-Induced Kindling in Rats :

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العنوان

Role of Inflammation in Pentylenetetrazole-Induced Kindling in Rats :

المؤلف

Abd El-Samii, Basma Ataf Abd El-Ghafour.

هيئة الاعداد

باحث / Basma Ataf Abd El-Ghafour Abd El-Samii

مشرف / Yasser Mohamed Ahmed Mustafa

مشرف / Sawsan A. Zaitone

مشرف / Nabila Nour Eldin

الموضوع

Aspirin. Epilepsy. Celecoxib.

تاريخ النشر

2016.

عدد الصفحات

179 p. :

اللغة

الإنجليزية

الدرجة

ماجستير

التخصص

الصيدلة

تاريخ الإجازة

1/1/2016

مكان الإجازة

جامعة قناة السويس - كلية الصيدلة - الادوية والسموم

الفهرس

Only 14 pages are availabe for public view

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Abstract

The current study aimed to investigate the effect of celecoxib, aspirin and -3polyunsaturated fatty acids (3- PUFAs) on seizure activity and neurodegeneration in pentylenetetrazole (PTZ) –kindled rats focusing on their effect on production of lipoxinA4 (LXA4)and expression of formyl peptide rdceptor-like1 (FPRL1) receptors.Preteratment with aspirin and 3- PUFAs reduced convulsive behavior exhibited by rats, level of LXA4 and the percent of degenerative cells in the brain compared to PTZ-kindled rats.