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العنوان
Chemical reactivity of 6-methylchromone-3- carbonitrile towards some nucleophilic reagents /
المؤلف
Mohamed, Sara Said El-sayed.
هيئة الاعداد
باحث / سارة سعيد السيد محمد
مشرف / صلاح سيد ابراھيم
مشرف / مجدي أحمد محمد
مشرف / ناصر محمد عبدالفتاح الجوھرى
تاريخ النشر
2015.
عدد الصفحات
219 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة عين شمس - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

A new series of chromeno[2,3-b]pyridines was efficiently synthesized throughout chemical transformations of 6-methylchromone-3-carbonitrile (1) with some active methylene compounds bearing –CH2-CN and –CH2-CO- moieties. Some chromeno[3’,2’:5,6]pyrido[2,3-d]pyrimidines were also synthesized. New series of heteroannulated chromeno[2,3-b]pyridines were easily and efficiently synthesized from DBU catalyzed condensation of 2-amino-6-methylchromone-3-carboxaldehyde (14) with a variety of heterocyclic enols and enamines namely, 4-hydroxycoumarin, 4-hydroxy-1-methylquinolin-2(1H)-one, 2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one, 4-hydroxy-2H-pyrano [3,2-c]quinoline-2,5(6H)-dione, 4(6)-aminouracil and 5-amino-3-methyl-1H-pyrazole. Structures of the new synthesized products were deduced on the basis of their analytical and spectral data. The synthesized compounds were screened in vitro for their antimicrobial activities.