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Abstract The aim of this study was to assess the frequencies of CD14++CD16+, peripheral blood monocytes in asthmatic patients. This study was carried out on sixty patients (25 males and 35 females), their ages ranged between 16 and 80 years old, in addition to 25 apparently healthy volunteers as a control group (13 males and 12 females), their ages ranged between 19 and 70 years, divided into four groups: group I (Control group): This group included 25 apparently healthy volunteers. group II: 20 Patients with completely controlled asthma. group III: 20 Patients with partly controlled asthma. group IV: 20 Patients with uncontrolled asthma. The results showed the following: No statistical significance between controlled asthma, partly controlled asthma, uncontrolled asthma and control group as regard age and sex. Highly statistical significant increase between controlled asthma, partly controlled asthma, uncontrolled asthma, and control group as regard number and percent distribution of symptoms, this can be explained by variable degree of asthma control and management. Highly statistical significant increase between controlled asthma, partly controlled asthma, uncontrolled asthma, and control group as regard percent of CD14++CD16+ cells, this can be explained by increased values of CD14++CD16+ cells with increased degree of severity and poor controlling of asthma. Highly statistical significant increase between controlled asthma, partly controlled asthma, uncontrolled asthma, and control group as regard Mean Fluorescence Intensity (Mx) and (My) of CD14++CD16+ cells, as levels increased as chronicity and severity of asthma increased. No significant correlation between CD14++CD16+ cells% and age, highly significant correlation between CD14++CD16+ cells% and CRP, ESR, IgE, WBCS, neutrophils and eosinophils. Positive correlation between CD14++ CD16+ cells and IgE among controlled asthma, partly controlled asthma, uncontrolled asthma, and control group. |