الفهرس | Only 14 pages are availabe for public view |
Abstract P.aeruginosa is one of the most commonly occurring pathogens causing a wide variety of nosocomial infections. The control of such infections depends on accurate epidemiological investigation to trace the source of P.aeruginosa hospital outbreaks. Different epidemiological typing techniques have been proposed for this purpose. This work was held to investigate clinical and microbiologic characteristics of the nosocomial infections caused by P.aeruginosa strains in surgical wards, and to bring up the cross-transmission level of this opportunistic pathogen in a university hospital. Seventy-eight P.aeruginosa strains were isolated from clinical and environmental specimens. The isolation rate of P.aeruginosa was (5.1%). This rate was higher for septic surgical wound infections than any other source (41.2%). These isolates were typed using six different phenotypic and genotypically based epidemiological markers: serotyping, antibiogram typing, pyocin typing, extracellular enzyme profile typing, ribotyping, and PFGE typing. Antimicrobial resistance in P.aeruginosa is one of the most important factors limiting the control of these infections, frequently leading to treatment failure with major clinical consequences. A multi-resistant pattern can be the first clue that draws the attention of the physician and of the members of the Committee of Nosocomial Infections. In this study, resistance to Augmentin and to Ceftazidime was found to be higher (98.7%) than to other used antimicrobials, while Imipenem resistance was the lowest (37.2%). |