الفهرس 
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Abstract
Introduction:
Cirrhosis is a major health problem worldwide. It is associated with alterations in the gastrointestinal mucosa, with increased risk for peptic ulcer disease. Portal hypertensive gastropathy (PHG) is one of the clinically important gastric mucosal lesions because it may cause acute or chronic gastrointestinal blood loss. The prevalence of PHG varies widely; frequencies from 4% to 98% have been recorded in studies of patients with portal hypertension. prevalence of PHG is shown to be closely associated with the severity of cirrhosis assessed by Child-Pugh classification.
Infection by H. pylori is highly prevalent, especially in low socioeconomic strata of developing countries. In patients with liver cirrhosis, their prevalence is controversial –as well as the existence with PHG .meta-analysis by (Vergara et al ,2006) which included seven studies that assessed the prevalence of H. pylori infection and endoscopic lesions associated with cirrhosis, concluded that infection by H. pylori was present in 60.7% of the patients with increased risk of developing peptic ulcer. However, in another study, Batmanabane et al ,2014 )from India concluded that PHG does not provide a favorable environment for colonization by H. pylori, suggesting no contribution of the bacteria in the pathogenesis of PHG.
If H. pylori infection is found to contribute to the pathogenesis of PHG, then eradication of H. pylori should be beneficial in the management of PHG bleeding which usually results in anemia.
The study was carried out in sohag university hospital, from September 2016-March2017. Our study included 50 Cirrhotic patients. Cirrhotic patients with endoscopic diagnosis of PHG enrolled as cases and cirrhotic patients without PHG enrolled as controls. . Gastric biopsy was taken from all patient for detection of H.Pylori by histopathological examination.
The diagnosis of cirrhosis made by a combination of abdominal ultra sonography, liver function tests (prothrombin time and serum albumin), and, informed consent obtained from all patients.
Results:
Our study was carried-out in sohag university hospital .Our study included 50 Cirrhotic patients. Cirrhotic patients with endoscopic diagnosis of PHG enrolled as cases and cirrhotic patients without PHG enrolled as controls. our study showed no significant difference between prevelance of H.pylori in patients with and without PHG , also there was no association between severity of PHG and H pylori infection.