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Abstract In recent years, the immunostimulating medicinal plants are being studied extensively with great interest which have desirable effects on disease prevention not only by directly affecting on pathogen but also by stimulating natural and adaptive defense mechanism of the host. from this medicinal plants garlic and Echinacea purpurea. Collibacillosis in Egypt and all over the world is considering one of the most chronic bacterial disease. So this study aim to control the collibacillosis by using immunostimulant medicinal plants as garlic and Echinacea Purpurea by elevate the immune status and performance of bird to face the E.coli. This study done on one hundred and twenty (120) chicks, one day old, commercial Hubbard chicks obtained from commercial hatchery of Zagazig Poultry Company, divided equally into 6 groups of each 20 chicks. group 1: chicks kept as normal control. group 2: chicks administrated garlic 1 gm/kg feed for 42 days. group 3: chicks administrated Echinacea purpurea 5 mg/kg feed for 42 days. group 4: chicks infected orally by1 ml E. coli O78 (3x 107 CFU) intra crop at 10th days old. group 5: chicks administrated garlic 1 gm/kg feed from one day old then infected orally by 1 ml E. coli O78 (3x 107 CFU) intra crop at 10th days old. group 6: chicks administrated Echinacea purpurea 5 mg/kg feed from one day old then infected orally by 1 ml E. coli O78 (3x 107 CFU) intra crop at 10th days old. |