الفهرس 
Sickle Cell DiseaseOnly 14 pages are availabe for public view
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Abstract
Sickle cell disease is an autosomal recessive disorder. The
result of inserting Valine in place of a glutamic acid in the β-globin
gene on chromosome 11. This lead to synthesis of (HbS) rather than
(HbA). Its manifestation is due to hemolysis and repeated vasoocclusion
which affect every organ ending in multiple organ
damage.
In SCD, hemoglobin molecules contain a set of abnormal
amino acids that cause an abnormal reaction to transporting oxygen
throughout the body. They stick together and form long, twisted
chains in a process called polymerizing that deforms the red blood
cells. These sickled cells can no longer move freely through the
smaller arteries and veins; instead, they clump together and stick to
vessel walls. The results can include pain throughout the body,
damage to organs, and strokes.
Management of this disease through many years depended
on hydroxyurea, stem cell transplantation, gene therapy and blood
transfusion which is associated with iron over load which must be
treated by iron chelators.
The aim of this work was to assess the level of ADMA and
its correlation to cerebral blood flow in children with sickle cell
anemia.
This study was done after approval from Ethical committee
of research center of Tanta University Hospital. This study was done
on 30 patients with sickle cell anemia who were attendant of
Hematology Unit, Pediatric department, Tanta University, their ages
Summary & Conclusions
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ranged from 6-18 years and 30 healthy children as a control group,
their ages ranged from 6-18 years.
All patients of this study were submitted to the following:
1. Complete history taking.
2. Thorough clinical examination.
3. Laboratory investigations including:
Complete blood count.
Reticulocyte count.
LDH.
Hemoglobin electrophoresis.