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العنوان
A Systematic Review of Functional Outcomes of Autologous Chondrocyte Implantation and Mosaicplasty in Treatment of Articular Knee Cartilage Defects /
المؤلف
Alnaggar, Hamdy Essam Hamdy.
هيئة الاعداد
باحث / حمدي عصام حمدي النجار
مشرف / طارق محمد خليل
مشرف / شريف أحمد الغزالي
تاريخ النشر
2017.
عدد الصفحات
56 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
جراحة العظام والطب الرياضي
تاريخ الإجازة
1/1/2017
مكان الإجازة
جامعة عين شمس - كلية الطب - جراحة العظام
الفهرس
Only 14 pages are availabe for public view

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from 56

Abstract

Osteochondral lesion is a major problem affecting large population with many available modalities of treatment.
This study compare mosaicplasty to ACI with considering the functional outcome as the point of interest, taking in consideration the difficult technique of mosaicplasty, the high cost and the long duration of treatment in ACI in a trial to reduce the need of future replacement surgeries, lowering the arthritis accompanying the disease and may be return to previous function specially in athletes.
11 studies were chosen from the database search according to the inclusion criteria, and the results were pooled to reach a final statistical figure of improvement in the above 2 techniques and we concluded that there was no significant difference between ACI and mosaicplasty as regard functional outcome in short follow up period making mosaicplasty a more convincing modality of treatment as ACI is higher in cost, duration and is a two stage operation unlike mosaicplasty, however, figures of long term follow up suggests the superiority of ACI in the treatment of chondral defects and decline in follow up figures in mosaicplasty technique.
There is evident gap of knowledge due to the lack of well-designed RCT’s of the various treatments used for management of patients, the diversity of techniques, functional outcome score and the rehabilitation programs.
The heterogeneity made it difficult to reach a conclusion that was strong enough, so more high-quality randomized controlled trials and other clinical trials are needed with unified criteria, surgical techniques and long-term follow up.