الفهرس 
Cardiac BiomarkersOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusion
Major cardiac complications after cardiac surgery can
substantially affect outcome (Smith RC et al. 1991).
Early diagnosis and risk stratification are therefore important
issues to develop therapeutic goals that could improve patient care.
Therefore, reliable biologic markers as predictors of the occurrence
of short and long term cardiac complications would be helpful in
routine clinical practice (Jaffe AS et al. 2000).
The B-type natriuretic peptide (BNP) is a neurohormone
mainly secreted from cardiac ventricles by increasing ventricular wall
stress and volume expansion (Hunt PJ et al. 1997).
In response to the appropriate stimulus, BNP is finally cleaved
into BNP and NT-proBNP which is more stable that makes its
measurement more reliable (Hunt PJ et al. 1997).
The objectives of this work were to find out the prognostic
value of NT-proBNP as a valuable marker in predicting postoperative
myocardial insult, short term outcome in patients undergoing open
heart and evaluate the independency of this biomarker.
Thirty five patients who had cardiac surgery in our department
were enrolled in this study their ages ranged from 22 to 68 years, and
they were 14 males and 21 females.
Written informed consent was obtained from all patients
included in the study. The study was approved by the Ethics
Committee of Faculty of Medicine, Tanta University.